45 year old female.
Previous intraocular / retinal procedure with retinal membrane peel.
Recurrent retinal traction necessitating further retinal membrane peel.
The figures show the recurrent peeled membrane.
The spindle cells in figure 1 are positive for cytokeratins.
Some of the arrowed cells in figure 3 are positive for CD68.
1. The spindle cells are mostly trans-differentiated RPE cells. The retention of cytokeratin is very useful to identify them as altered RPE cells. There are also some similar appearing myofibroblasts and fibroblasts in the tissue.
2. Emulsified silicon oil that is intra- and extracellular in location.
3. Recurrent proliferative vitreoretinopathy in the presence of vitreous substitute (silicon oil).
4. Macrophages +/- giant cells.
An excellent review by Paul Hiscott: Vitreous biopsy pathology: New kid on the block. Current Diagnostic Pathology, 2001, volume 7, p45-55.