Case Study: August 2012
- A 60-year-old male presents with an abnormal ocular surface lump at the limbus.
- This was excised. The main lesion is shown in Fig 1.
- The background interpalpebral conjunctiva in both eyes demonstrated brown pigmentation. This was also biopsied and shown in Fig 2 (epithlium) and 3 (substantia propria).
- What does Fig 1 show?
- What do Figs 2 and 3 show?
- Which drugs can cause the appearance in Figs 2 and 3?
Click to show answers
- In situ squamous carcinoma.
- Increased melanin granules in basal cells and melanin granules in substantia propria macrophages (Masson Fontana positive).
- Chlorpromazine and epinephrine bitartrate, borate, and hydrochloride (leading specifically to increased melanin granule content). This patient was taking Chlorpromazine tablets..