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Case Study: June 2012
History
- A 55 year old presents with a retina detachment.
- It is repaired but the patient represents with complications.
- Subretinal pathology is observed which is biopsied.
- See figures.
Questions
- Which procedure was carried out as part of the repair for the original retinal detachment?
- What are the key features seen in the histology?
- Which immunohistochemical marker(s) will stain the pigment containing cells?
Click to show answers
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- Silicon oil tamponade agent.
- This is subretinal PVR. Note the almost hyaline core strand composed of neo-basement membrane and collagen covered in RPE.
- A CK7 will stain the transdifferentiating RPE cells and a CD68 will light up the macrophages containing silicon oil and RPE melanosomes.
References
- Subretinal strands: ultrastructural features. Trese MT, Chandler DB, Machemer R.Graefes Arch Clin Exp Ophthalmol. 1985;223(1):35-40.
- Subretinal proliferation.Sternberg P Jr, Machemer R.Am J Ophthalmol. 1984 Oct 15;98(4):456-62.
