Case Study: November 2011


  • 50 year old woman.
  • 3 year history of well defined cream lesion at limbus.
  • Removed.
  • See figures.


  1. The lesion was focally positive for CD34, Factor 13a, CD68, ASMA and negative for neurofilament, Melan A, S100, HMB45, cytokeratin and showed no pleomorphism, necrosis or mitotic activity. Which further immuno markers may assist in securing a diagnosis?
  2. What is the diagnosis?
Click to show answers
  1. CD57 (NK1-C3) was strongly positive on all the cells.
  2. Epithelioid fibrous histiocytoma of the limbal conjunctiva.