Case Study: October 2013


  • 65 year old female with some odd stringy vitreous deposits, looking like ‘cobwebs’
  • Apart from cataracts-fit.
  • Fig1-H and E
  • Fig 2-Congo Red
  • Fig 3-Polarsised optics.


The diagnosis is straightforward here.

  1. The question is under what clinical scenarios is this pathological appearance seen?
Click to show answers

This is vitreous amyloid.

  1. The following scenarios are associated with vitreous amyloid:
  • Primary familial amyloidosis
  • Familial amyloid polyneuropathy
  • Non-familial vitreous amyloidosis (primary or secondary to systemic amyloid).